PAPILOCARE 77 CANNULAS MODE OF USE

This Papilocare 77 cannulas product variation is intended for a woman’s full 6 month application. The full application duration is 6 months, which can be extended for longer based on the medical advice. It is important to complete the full length of treatment in order to obtain the desired results.

It is recommended to start treatment after menstruation.

First month: One cannula should be applied per day, for 21 consecutive days, then take the next 7 days off.

Months 2 to 6: One cannula should be applied every other day for 21 days.

The recommendation to pause treatment with Papilocare during menstruation has to do with patient comfort, and not because there is any clinical incompatibility.

Papilocare should ideally be used just before bedtime. It is compatible with the use of condoms.

HOW TO APPLY 

Papilocare is supplied in single-use vaginal cannulas. Any cannula that appears open or broken should be discarded. The cannula is designed to aid in the product’s application. For application, lay on your back. The cannula should be inserted into the vagina, then press to release its contents. Then, remove it from the vagina, while continuing to press the cannula, in order to not suction out the product already applied.

It is possible that a small amount of gel remains in the cannula. This dose not mean that a dose less than what is recommended has been administered, as the cannula releases a sufficient amount to cover the cervical-vaginal mucosa (3 ml). Once the cannula is used, it should be discarded. A cannula should not be reused nor shared between two patients.

INGREDIENTS & ACTIONS

• Coriolus Versicolor Extract (Re-epithelialising and restorative action for cervical-vaginal lesions and microlesions)

• Neem Extract [Azadirachta indica] (Emollient properties that promote the natural healing process)

• Hyaluronic Acid Niosomes (Hydrating action to help maintain tissue elasticity)

• β-Glucan Niosomes (Antioxidant properties that maintain the structure and natural functionality of the skin and mucous membranes)

• Centella Asiatica Phytosomes (Acts to repair mucosal lesions)

• BioEcolia® [α-glucan oligosaccharide] (A prebiotic that stimulates the growth of beneficial bacterial flora and rebalances the microbiota in the cervical-vaginal zone)

• Aloe Vera Extract (Hydrating, re-epithelialising and restorative action for the cervical-vaginal zone)

Can Papilocare® Vaginal Gel be used with a vaginal ring (NuvaRing or Estring)?

There is no data pertaining to Papilocare® Vaginal Gel in patients using vaginal contraceptives. Indeed, these patients have always been excluded from Papilocare® Vaginal Gel research studies (exclusion criteria: use of vaginal contraceptives or other vaginal hormonal treatments). Therefore, as a precaution, it is better not to use Papilocare® Vaginal Gel in patients wearing a vaginal contraceptive. In any case, as it is not an absolute contraindication, it will always be the doctor who assesses the benefits and risks and determines the timing of the prescription.

Papilocare 77 Cannulas

This 77 Cannula product variation is intended for a woman’s full 6 month Papilocare application.

Who can use Papilocare?

The use of Papilocare is recommended in women (over 18 years of age) infected by the human papillomavirus (HPV), independently of whether they have virus-induced lesions (ASCUS or LSIL).

What is Papilocare and how does it work?

Papilocare is the first clinically proven treatment solution for HPV-induced low grade (ASCUS, LSIL, CIN 1) lesions of the cervical transformation zone. The Coriolus versicolor-based vaginal gel is specifically formulated to activate the three modifiable HPV-induced low grade lesion repair factors.

1. Re-epithelialisation of the cervical transformation zone

2. Rebalancing the vaginal microbiota

3. Counteracting the non-inflammatory microenvironment that HPV creates.